Sclero-cornea and defective mesodermal migration

Sclero-cornea and defective mesodermal migration.

A 5-month-old boy with bilateral sclero-cornea, multiple systemic abnormalities, and normal karyotype had his left eye removed after corneal perforation. Histopathological examination of the enucleated eye revealed an irregular corneal epithelium, absent Bowman's membrane, thickened and vascularized stromal lamellae, absent Descemet's membrane and endothelium, no angle structures, hypoplasia of...

Looks like multiple sclero

Positive ANAs are found in ordinary people A fairly standard definition of an abnormal ANA titre is 1 : 40, which has a prevalence in normal people of between 5 and 35%, usually higher in women. Of course, the prevalence of antibody positivity changes as the cursor shifts: 32% of normal adults were positive at 1 : 40 in one study, 13% at 1 : 80, 5% at 1 : 160 and only 3% at 1 : 320 (Craig et al...

20-P017 Visualizing mesodermal cell migration in chicken embryo

The WAS protein (WASp) coordinates actin polymerization at the leading edge of migrating cells and is defective in patients suffering from Wiskott Aldrich syndrome, resulting in severe immunodeficiency. To model this disease we are using translucent Zebrafish larvae and have begun to characterise a newly derived WASp mutant. The mutant codes for a heavily truncated protein, which we are assayin...

Sclero-Corneal Trephining

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

Toddler/Apela/Elabela is a conserved secreted peptide that regulates mesendoderm development during zebrafish gastrulation. Two non-exclusive models have been proposed to explain Toddler function. The 'specification model' postulates that Toddler signaling enhances Nodal signaling to properly specify endoderm, whereas the 'migration model' posits that Toddler signaling regulates mesendodermal c...